Table 4.
Case examples for adding 9p21 genotype to traditional risk factors based ARIC Cardiovascular Risk Score (ACRS) risk model
| Subject # | 1 | 1 | 1 | 2 | 2 | 2 |
|---|---|---|---|---|---|---|
| Sex | Male | Male | Male | Female | Female | Female |
| Age | 51 | 51 | 51 | 55 | 55 | 55 |
| Current smoking | No | No | No | Yes | Yes | Yes |
| Total cholesterol (mg/dL) |
200 | 200 | 200 | 240 | 240 | 240 |
| HDL-C (mg/dL) | 40 | 40 | 40 | 40 | 40 | 40 |
| LDL-C (mg/dL) | 135 | 135 | 135 | 150 | 150 | 150 |
| Family history | No | No | No | No | No | No |
| Antihypertensive medication use |
No | No | No | Yes | Yes | Yes |
| Systolic blood pressure (mm Hg) |
120 | 120 | 120 | 155 | 155 | 155 |
| Diabetes mellitus |
No | No | No | No | No | No |
| ACRS risk (%) | 9.0 | 9.0 | 9.0 | 17.7 | 17.7 | 17.7 |
| 9p21 genotype | AA | AG | GG | AA | AG | GG |
|
ACRS+9p21 risk (%) |
7.5 | 9.0 | 10.6 | 15.0 | 17.6 | 20.7 |