Table 2.
Change in nerve function over time
| Variables MNCV (m/s) | n | Baseline | 6 Months | |
|---|---|---|---|---|
| Δ | P* | |||
| Epalrestat | 219 | 51.96 ± 4.49 | +0.29 ± 3.11 | 0.214 |
| P‡ | 0.002 | 0.013 | ||
| VPT (s) | ||||
| Epalrestat | 678 | 8.01 ± 3.43 | +0.57 ± 3.21 | 0.110 |
| P‡ | 0.147 | 0.095 | ||
Data are means ± SD, unless otherwise indicated. Δ, change vs. baseline.
*
P values were calculated using paired t test and
‡
two-sample t test, and VPT was measured on the medial malleolus in the low extremities, using a 128-Hz tuning fork by measuring the number of seconds until the patient could no longer feel the vibrations after the tuning fork was placed on the medial malleolus.