Table 5.
Effect of H. indicus extract on liver and kidney TBARS, hydroperoxides, and malondialdehyde in normal and streptozotocin induced diabetic rats
| Groups | Dose (mg/kg bw/day) | TBARS (mM/mg) | Hydroperoxides (nM/100 g tissue) | Tissue MDA (nmol/g wet weight) | |||
|---|---|---|---|---|---|---|---|
| Liver | Kidney | Liver | Kidney | Liver | Kidney | ||
| Normal | 35 ml/water | 0.68 ± 0.21 | 1.53 ± 1.08 | 70.64 ± 2.10 | 55.03 ± 2.09 | 295.4 ± 1.69 | 291.23 ± 1.02 |
| Diabetic control | 35 ml/water | 1.45 ± 0.01 | 2.64 ± 0.36 | 115.57 ± 1.45 | 79.00 ± 1.01 | 365.3 ± 1.20 | 365.23 ± 1.65 |
| Diabetic + tolbutamide | 100 | 1.12 ± 1.01* | 1.91 ± 0.27* | 84.13 ± 1.32* | 65.13 ± 1.11* | 345.65 ± 1.02* | 300.95 ± 1.24* |
| Diabetic + H. indicus | 500 | 0.98 ± 1.01* | 1.75 ± 0.08* | 72.29 ± 0.13* | 58.63 ± 1.30* | 310.21 ± 1.54* | 280.56 ± 1.36* |
Each value is mean ± SD for six rats in each group
*
Values are statistically significant when compared to diabetic control at F > 0.05 (ANOVA) and P < 0.05 (DMRT)