Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Two common protein-ligand interactions (anchor points), shared by all six series of active compounds binding in the DFG-in receptor conformation. An interaction with the hydrophobic pocket (dashed line) and hydrogen bonding to residues in the gatekeeper region are common to all six series of active compounds: (A) 2-aminopyrimidine carbamates, (B) 4-azaindoles, (C) aminopyrazoles, (D) benzimidazolones, (E) indole and pyridine fragments, and (F) triazolopyridine oxazoles.
