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A subset of bmh1 mutants are attenuated for virulence in the mouse model of systemic candidiasis. Mice were inoculated via tail-vein injection with 5×105 yeast cells of the WT, BMH1 control and mutant strains, and their disease progression was assessed for 30 days. Survival curves and statistical differences between strains were analysed by Prism software using the logrank test. K51E and L231S are superimposable on the graph.
