Table 3.

Tissue burden of murine tissues 48 h p.i

Strain	Median survival*	Right kidney [log10(c.f.u. g−1)], mean±sem	Left kidney [log10(c.f.u. g−1)], mean±sem	Spleen [log10(c.f.u. g−1)], mean±sem
WT	7	5.3±0.7	4.9±1.0	4.0±0.4
BH1P1	5.5	4.8±0.8	4.9±0.8	4.2±0.2
BMH	7	4.8±0.4	4.6±0.2	3.9±0.4
K51E	31	3.1±0.3†‡	2.9±0.6†‡	3.2±0.7
K51R	12	4.1±0.2	4.2±0.2	2.4±0.7
L231S	31	2.6±0.8†‡	2.1±1.3†‡	2.9±1.7
M125R	24.5	2.8±1.4†	2.7±1.2†‡	3.4±1.7
R142C	7	4.9±0.8	4.8±0.7	3.6±1.0

*Median survival of mice infected with control and mutant strains is shown for comparison. Results are presented as the mean±sem of two separate experiments with n=3 mice per experiment. Student's t test was used to determine differences between mean values.

†Significantly different from WT.

‡Significantly different from isogenic control (BMH). P<0.05 was considered significant.