Table 3.

Genes whose expression level in q-H2A-transfected cells was at least 4-fold higher or lower than in wt-H2A-transfected cells at 48 hr post-induction^a

A. q-H2A > wt-H2Ab

1. AP1S1, adaptor protein complex AP-1sigma 1[71]

2. BAZ2A, bromodomain adjacent to zinc finger; a putative chromatin remodeling factor; HAT-associated; in    pre-B acute lymphoblastic leukemia [42]

3. CLDN18, claudin 18. It regulates cell transformation/metastases and may serve as a marker for colon cancer    [31, 72, 73].

4. DPYSL4, dihydropyrimidinase-like 4. It is aberrantly expressed in Down syndrome [74].

5. EPHA2, member of the ephrin receptor subfamily of the protein-tyrosine kinase family associated with    ovarian and urinary tract cancers [75-77]

6. FGF2, member of the fibroblast growth factor family implicated in diverse biological processes including    tumor cells growth [78, 79]

7. GABARAPL1, GABA(A) receptor-associated protein; member of the microtubule-associated protein (MAP)    family [80]

8. GFR, nuclear protein: guanine nucleotide exchange factor. It may assist in neoplastic transformation and    growth of cells through RAS activation [43, 44]

9. GIPC2, a PDZ domain protein. It plays a role in carcinogenesis through growth factor signaling [38]

10. GYPA, glycophorin A; an erythroid-lineage-specific membrane sialoglycoprotein

11. KRTAP1-1, keratin associated protein (KAP) 1-1; forms keratin intermediate filaments

12. LACRT, lacritin; a secretion-enhancing factor. It is expressed in human breast tumors, breast cancer cell lines,    and in normal breast [81]

13. OSBPL11, an oxysterol-binding protein involved in regulation of cholesterol balance

14. REPS1, RALBP1-associated Eps domain. It plays an important role in the Ras-RalGDS signal transduction    pathways [82] and is associated with cancer [83].

15. RNF7, a ring finger protein; member of ubiquitin ligase complex important for cell cycle progression and    signal transduction; involved in HIF activity regulation [84]

16. USH1C, harmonin; expressed in inner ear sensory cells

17. VEGF, vascular endothelial growth factor. It is essential for neovascularization of tumors [26].

B. q-H2A < wt-H2Ab

1. HIST1H2AJ, histoneH2aj

2. METAP2, methionyl aminopeptidase 2 overexpressed in colorectal and colon cancers [85]

3. RGS8, regulator of G-protein signaling selectively expressed in NK cells [86] and also in hereditary prostate    cancer [87]

^aSymbols and functional data according to PubMed Protein. Selected additional, more specific references are given in brackets

^bIn addition to the above genes, 19 genes of unknown function were expressed differentially (16 for q-H2A > wt-H2A plus 3 for q-H2A < wt-H2A)