Table 3.

Multivariable-adjusted associations of PC, lipid, and lipoprotein measures with incident cardiovascular or coronary events in 4,368 individuals

Measure	Cardiovascular events (N=377)			Coronary events (N=206)
	HR	95% CI	P value	HR	95% CI	P value
PC1*	1.10	0.99–1.22	0.07	1.11	0.97–1.28	0.12
PC2*	1.22	1.08–1.36	0.001	1.24	1.06–1.45	0.008
PC3*	0.81	0.71–0.92	0.001	0.76	0.64–0.91	0.003
HDL-C	0.72	0.63–0.82	< 0.001	0.72	0.61–0.86	< 0.001
LDL-C	1.10	0.99–1.21	0.08	1.20	1.04–1.37	0.01
TG	1.12	1.00–1.25	0.04	1.07	0.92–1.25	0.36
Non-HDL-C	1.10	1.00–1.21	0.06	1.13	0.99–1.28	0.08
HDL-S	0.87	0.77–0.99	0.04	0.78	0.64–0.95	0.01
HDL-L	0.76	0.66–0.88	< 0.001	0.75	0.61–0.91	0.003
LDL-VS	1.03	0.92–1.14	0.66	1.02	0.88–1.18	0.82
LDL-S	1.14	1.04–1.25	0.004	1.16	1.04–1.31	0.01
LDL-M	1.17	1.07–1.28	0.001	1.19	1.06–1.34	0.005
LDL-L	1.09	0.98–1.20	0.11	1.09	0.95–1.24	0.23
IDL-S	0.91	0.81–1.02	0.10	0.93	0.79–1.09	0.37
IDL-L	1.05	0.95–1.17	0.31	1.09	0.95–1.24	0.23
VLDL-S	1.02	0.91–1.13	0.79	1.05	0.91–1.21	0.52
VLDL-M	1.05	0.95–1.16	0.38	1.06	0.93–1.22	0.38
VLDL-L	1.06	0.96–1.17	0.24	1.06	0.93–1.21	0.40
LDL total	1.16	1.05–1.28	0.004	1.17	1.03–1.34	0.02
Non-HDL	1.10	1.00–1.21	0.06	1.13	0.99–1.28	0.08
HDL total	0.78	0.68–0.90	0.001	0.71	0.58–0.87	0.001
LDL/HDL	1.22	1.12–1.32	< 0.001	1.21	1.09–1.35	< 0.001
LDL/HDL-L	1.25	1.14–1.36	< 0.001	1.22	1.09–1.37	0.001
Non-HDL/HDL	1.20	1.11–1.30	< 0.001	1.20	1.08–1.33	0.001
Non-HDL/HDL-L	1.25	1.15–1.37	< 0.001	1.23	1.09–1.38	0.001
LDL-S+M/HDL-L	1.20	1.10–1.30	< 0.001	1.20	1.08–1.33	0.001
Peak LDL diameter	0.87	0.78–0.97	0.009	0.84	0.73–0.97	0.02

Hazard ratios (HR) and 95% confidence intervals (CI) are per one standard deviation of the measure. Values shown are adjusted for age, gender, systolic blood pressure, use of antihypertensive medications, diabetes status, and current smoking status.

^*Values for PC1, PC2, PC3 were calculated in a single regression model including all three PCs.