Table 6.
Multivariable-adjusted associations of SNPs to selected lipoprotein measures
| SNP | Locus | Alleles maj/min/ MAF |
HDL-C P value |
LDL-C P value |
TG P value |
HDL-L P value |
LDL-S P value |
LDL-M P value |
PC1 P value |
PC2 P value |
PC3 P value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs693 | APOB | G/A/0.48 | 0.002 | 3×10−11 | 0.0002 | 0.03 | 0.04 | 0.01 | 2.7×10−8 | 0.74 | 0.17 |
| rs4420638 | APOE | A/G/0.20 | 0.02 | 3×10−21 | 0.006 | 0.16 | 2×10−10 | 3×10−12 | 8.7×10−7 | 0.029 | 0.94 |
| rs6511720 | LDLR | G/T/0.10 | 0.36 | 1×10−15 | 0.49 | 0.39 | 0.71 | 0.37 | 0.003 | 0.028 | 0.10 |
| rs646776 |
CELSR2/ PSRC1/ SORT1 |
A/G/0.24 | 0.17 | 2×10−11 | 0.21 | 0.75 | 0.03 | 0.02 | 5.7×10−5 | 0.65 | 0.28 |
| rs1800775 | CETP | C/A/0.49 | 3×10−29 | 0.002 | 0.23 | 8×10−16 | 0.003 | 0.03 | 0.02 | 4×10−5 | 0.0005 |
| rs1800588 | LIPC | C/T/0.21 | 2×10−10 | 0.87 | 0.16 | 5×10−10 | 8×10−5 | 0.01 | 0.93 | 1×10−9 | 0.69 |
| rs4846914 | GALNT2 | A/G/0.40 | 1×10−6 | 0.34 | 0.003 | 0.0006 | 0.009 | 0.002 | 0.37 | 2×10−5 | 0.42 |
| rs1260326 | GCKR | C/T/0.36 | 0.28 | 0.78 | 5×10−9 | 0.22 | 0.02 | 0.003 | 0.16 | 0.005 | 0.24 |
| rs17145738 | MLXIPL | C/T/0.13 | 0.003 | 0.34 | 3×10−8 | 0.0007 | 0.0001 | 1×10−4 | 0.04 | 9×10−7 | 0.85 |
| rs3133506 | APOA1/A5 | T/G/0.07 | 0.003 | 4×10−5 | 2×10−15 | 0.004 | 6×10−5 | 4×10−7 | 0.004 | 7×10−5 | 0.40 |
| rs328 | LPL | C/G/0.09 | 3×10−12 | 0.50 | 2×10−9 | 4×10−6 | 4×10−5 | 0.0001 | 0.002 | 7×10−6 | 0.04 |
P values shown are adjusted for age, gender, and diabetes status. The major allele, minor allele, and minor allele frequency (MAF) for each SNP is indicated; all modeling was performed with the major allele as the reference allele.