Table 3.
Secondary End-Points: Perioperative blood loss, transfusion and fluid requirements*
| EACA (n = 91) |
Placebo (n = 91) |
P Value | |
|---|---|---|---|
|
Estimated blood loss | |||
| Intraoperative | |||
| Mean | 2938 ± 2315 | 3273 ± 2195 | 0.32 |
| Median | 2200 (1000,4000) | 2700 (1600,4400) | 0.12 |
| Post-surgery - POD 1 | |||
| Mean | 3265 ± 2416 | 3695 ± 2341 | 0.23 |
| Median | 2440 (1300,4605) | 3020 (2095,4625) | 0.08 |
| Allogeneic RBC units transfused per patient | |||
| Intraoperative | 3.9 ± 3.7 | 4.2 ± 3.6 | 0.63 |
| Post-surgery - POD 2 | 1.4 ± 1.6 | 1.9 ± 2.6 | 0.13 |
| POD 3 – POD 8 | 0.6 ± 1.0 | 0.9 ± 1.2 | 0.12 |
|
Autologous RBC units transfused per patient | |||
| Intraoperative | 0.4 ± 1.1 | 0.6 ± 1.3 | 0.31 |
| Post-surgery - POD 2 | 0.0 ± 0.1 | 0.0 ± 0.1 | 1.0 |
| POD 3 – POD 8 | 0.0 ± 0.2 | 0 ± 0 | 0.32 |
| Intraop - POD 8 | 0.4 ± 1.1 | 0.6 ± 1.4 | 0.27 |
|
Allogeneic and autologous RBC units transfused per patient | |||
| Intraoperative | 4.3 ± 4.0 | 4.8 ± 3.8 | 0.43 |
| Post-surgery - POD2 | 1.4 ± 1.6 | 1.9 ± 2.6 | 0.13 |
| POD 3 – POD 8 | 0.6 ± 1.0 | 0.9 ± 1.2 | 0.09 |
| Intraop - POD 8 | 6.4 ± 4.9 | 7.6 ± 5.5 | 0.12 |
|
Fresh Frozen Plasma units transfused per patient | |||
| Intraoperative | 2.7 ± 3.9 | 2.6 ± 3.4 | 0.95 |
| Post-surgery - POD 2 | 0.1 ± 0.6 | 0.9 ± 4.0 | 0.10 |
| POD 3 – POD 8 | 0.0 ± 0.2 | 0.0 ± 0.2 | 1.00 |
| Intraop - POD 8 | 2.8 ± 3.9 | 3.5 ± 6.0 | 0.37 |
|
Platelet units transfused per patient | |||
| Intraoperative | 1.1 ± 3.1 | 1.3 ± 3.2 | 0.62 |
| Post-surgery - POD 2 | 0.1 ± 0.7 | 0.6 ± 2.9 | 0.12 |
| POD 3 – POD 8 | 0 | 0 | -- |
| Intraop - POD 8 | 1.2 ± 3.1 | 1.2 ± 4.8 | 0.23 |
|
Cryoprecipitate units transfused per patient | |||
| Intraoperative | 0 | 0 | -- |
| Post-surgery - POD 2 | 0 | 0.0 ± 0.2 | 0.32 |
| POD 3 – POD 8 | 0 | 0 | -- |
| Intraop - POD 8 | 0 | 0.0 ± 0.2 | 0.32 |
|
All blood product units transfused per patient | |||
| Intraoperative | 8.1 ± 10.0 | 8.7 ± 9.3 | 0.65 |
| Post-surgery - POD 2 | 1.6 ± 2.2 | 3.4 ± 8.8 | 0.07 |
| POD 3 – POD 8 | 0.7 ± 1.1 | 0.9 ± 1.2 | 0.11 |
| Intraop - POD 8 | 10.4 ± 10.8 | 13.0 ± 14.9 | 0.17 |
|
Isotonic crystalloid administered per patient | |||
| Intraoperative | 6408 ± 3430 | 6348 ± 2729 | 0.90 |
| Post-surgery - POD 1 | 8041 ± 3651 | 8394 ± 3107 | 0.48 |
|
3% saline administered per patient | |||
| Intraoperative | 220 ± 437 | 387 ± 1128 | 0.19 |
| Post-surgery - POD 1 | 285 ± 531 | 453 ± 1158 | 0.21 |
|
Colloid (Hespan, albumin) administered per patient | |||
| Intraoperative | 186 ± 408 | 100 ± 252 | 0.12 |
| Post-surgery - POD 1 | 186 ± 408 | 100 ± 252 | 0.12 |
P values determined by two-sample t-test with unequal variances Mann-Whitney rank-sum test as appropriate. Plus-minus values are mean ± SD. Median expressed as median (IQR). POD is postoperative day. There was no significant difference in the mean or median estimated intraoperative blood loss between the two groups. The mean estimated blood loss from drain output post-surgery through POD 1 was similar between the two groups, however, median estimated blood loss from drain output post-surgery through POD 1 tended to be less in the EACA group. There were no significant differences between groups when transfusion during various intervals (intraoperative period only, post-surgery through POD 2 only, or POD 3 through POD 8 only) was evaluated. There were no significant differences between groups in the volume of isotonic crystalloid, 3% normal saline, or colloid administered.