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CXCR3-induced MMPs activation of osteosarcoma cells. K7M2 cells were subjected to chemotaxis assays in modified transwell chambers for 16 hr in response to CXCL10 in the presence or in the absence of AMG487 or GM6001. Then, the conditioned media were harvested and subjected to gelatin zymogram. The results shown are representative of 3 separate experiments.
