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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Biochem Pharmacol. 2009 May 27;78(7):795–802. doi: 10.1016/j.bcp.2009.05.022

Figure 1.

Figure 1

Concentration-Effect Curves of Activation of 86Rb+ Efflux by ABT-089. Mouse thalamic, striatal and cortical synaptosomes were stimulated with indicated concentrations of ABT-089 for 5 sec either in the absence (●) or presence (○) of 2 μM DHβE. Each point represents mean±SEM from five separate experiments. Curves are nonlinear fits of the data to the Michaelis-Menten equation. Stimulation elicited by 10 μM nicotine or 1000 μM nicotine plus 2 μM DHβE are shown for reference.