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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Biochem Pharmacol. 2009 May 27;78(7):795–802. doi: 10.1016/j.bcp.2009.05.022

Figure 6.

Figure 6

ABT-089 Stimulation of α-CtxMII-Resistant and α-CtxMII-Sensitive [3H]-Dopamine Release. [3H]-Dopamine release was measured in the absence or presence of 50 nM α-CtxMII as an α6β2* nAChR antagonist. α-CtxMII resistant release is that persisting in the presence of the toxin and α-CtxMII sensitive release was calculated as the difference in response in the absence and presence of the toxin. Each point represents the mean±SEM of five separate experiments. Results for the αCtxMII-resistant response were fit to the Michaelis-Menten equation (Panel A), while those for α-CtxMII resistant release were analyzed as a biphasic curve (Panel B). Values for the parameters are shown. [3H]-Dopamine release elicited by exposure to 10 μM nicotine is provided for reference.