Table 2.
Summary of current treatment data for subjects who received clozapine and lithium carbonate.
| Subject number | Nadir neutrophil count on first exposure (×103/μL) | Duration of first neutropenia (days) | Range of stable dosage of Clozapine (mg/day) | Range of dosage of Lithium Carbonate used in Clozapine escalation (mg/day) | Duration between initiation of Lithium and initiation of Clozapine (days) | Median ANC before initiation of Lithium | Median ANC after initiation of Lithium | p value# | Current Lithium Carbonate dosage (mg/day) | Duration of Lithium Carbonate Use (years) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1.05 | 54 | 350-400 | 450-900 | 7 | 1.76 | 2.77 | 7.3×10-6 | N/A | 0.2 |
| 2 | 0.95 | 5 | 350 | 900 | 0 | 1.46 | 2.75 | 0.00025 | 900 (450 bid) | 2.5 |
| 3 | 1.26 | 3 | 150-450 | 825-1350 | 84 | 1.97 | 2.06 | 0.14 | 500 (250 bid) | 7.2 |
| 4 | 1.12 | 58 | 300-400 | 900-1500 | N/A | 1.59 | 2.05 | 0.00053 | N/A | 6.2 |
| 5 | 1.44 | 14 | 400 | 600-1500 | N/A | 1.77 | 3.64 | 0.0027 | N/A | 3.3 |
| 6 | 1.41 | 27 | 350 | 600 | -18 | 2.02 | 3.64 | 0.00019 | 700 (350 bid) | 2.4 |
| 7 | 1.54 | 13 | 175-500 | 1050-1500 | 6 | 1.54 | 2.11 | 0.0022 | 1650 (900+750) | 2.0 |
#
Student t-test comparing ANC values before and after lithium carbonate initiation ANC = Absolute neutrophil count