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. Author manuscript; available in PMC: 2010 Aug 27.
Published in final edited form as: Vaccine. 2009 Jul 17;27(39):5299–5306. doi: 10.1016/j.vaccine.2009.06.101

Figure 5.

Figure 5

Proinflammatory cytokine/chemokine protein production is down-regulated in the spleens of vaccinated mice challenged i.t. with F. tularensis LVS. Groups of control and vaccinated mice were challenged i.t. with 6 LD50 F. tularensis LVS. At 3 days post-infection, the spleens (top panel) and livers (bottom panel) were dissected from each group, and the cytokines and chemokines listed were quantified by Bio-Plex cytokine bead array analysis. Data are the means ± SD derived from 4 mice treated comparably. A second experiment yielded similar results. *Vaccinated group is significantly less than control: P<0.05. IL-4 concentrations were too low to be detected (not shown).