TABLE 1.

Prevalences of PI-selected nonpolymorphic mutations in PI-naïve and PI-treated individuals^a

Consensus B reference amino acid	Position	Amino acid change	Mutation prevalence (%)		Presence of mutation on expert list fromb:
			PI naïve (n = 17,581)	PI treated (%) (n = 9,307)	H	A	R	I	L
L	10	F	0.24	12	√	√	√	√	√
		R	0.02	0.65	√	√		√	√
		Y	0	0.42	√				√
V	11	L	0.05	1.1			√
I	13	M	0.01	0.69
K	20	T	0.06	5.4	√	√	√	√	√
A	22	V	0.11	1.3					√
L	23	I	0.05	1.8	√		√		√
L	24	I	0.01	8.1	√	√	√	√	√
		F	0.08	0.92	√		√
		M	0	0.24
D	30	N	0.01	8.8	√	√	√	√	√
V	32	I	0.01	7.5	√	√	√	√	√
L	33	M	0	0.26			√
E	34	Q	0.09	4.4				√	√
		D	0.05	0.49
		N	0	0.14
L	38	W	0.01	0.36			√
K	43	T	0.12	7.6	√		√	√	√
		I	0.02	0.33
K	45	I	0.01	0.18			√		√
		V	0	0.15
M	46	I	0.30	30	√	√	√	√	√
		L	0.27	13	√	√	√	√	√
		V	0.06	0.68	√
I	47	V	0.05	7.2	√	√	√	√	√
		A	0	0.45	√	√	√	√	√
G	48	V	0	6.3	√	√	√	√	√
		M	0	0.82	√		√		√
		A	0	0.52	√		√
		L	0	0.16
		Q	0	0.13
I	50	V	0.02	2.8	√	√	√	√	√
		L	0.01	0.64	√	√	√	√	√
G	51	A	0.01	0.38
F	53	L	0.04	8.4	√	√	√	√	√
		Y	0.03	0.74	√	√		√	√
I	54	V	0	31	√	√	√	√	√
		L	0.01	4.7	√	√	√	√	√
		M	0	3.9	√	√	√	√	√
		A	0	1.8	√	√	√	√	√
		T	0.02	1.5	√	√	√	√	√
		S	0	1.2	√	√	√	√	√
K	55	R	0.25	9.6					√
		N	0.03	0.3
Q	58	E	0.24	8.8	√	√	√	√	√
I	66	F	0.03	2.3			√
		V	0.08	1.8
		L	0.01	0.64
C	67	F	0.03	1.8
		L	0.01	0.24
A	71	I	0.07	4.6	√	√	√	√	√
		L	0	0.64		√	√	√	√
G	73	S	0.03	13	√	√	√	√	√
		T	0	4.1	√	√	√	√
		C	0.01	2.0	√	√	√	√
		A	0	1.1	√	√	√	√
		V	0.01	0.24			√
T	74	P	0.06	2.6	√		√	√	√
		K	0.04	0.4
		E	0	0.19			√
L	76	V	0.01	4.4	√	√	√	√	√
P	79	A	0.12	1.4
V	82	A	0.03	29	√	√	√	√	√
		T	0.01	4.3	√	√	√	√	√
		F	0	2.4	√	√	√	√	√
		S	0.01	1.8	√	√	√	√	√
		C	0	0.93	√	√	√
		L	0.02	0.35	√		√	√	√
		M	0	0.28	√	√	√		√
N	83	D	0.02	1.0	√			√	√
		S	0.02	0.32
I	84	V	0.01	21	√	√	√	√	√
		A	0	0.27	√	√	√		√
		C	0	0.24	√		√
I	85	V	0.12	6.9		√	√	√	√
N	88	D	0.05	6.8	√	√	√	√	√
		S	0.05	2.1	√	√	√	√	√
		T	0.01	0.20	√
		G	0	0.19	√				√
L	89	V	0.10	5.9	√	√	√	√
		T	0.01	0.36	√	√	√
L	90	M	0.23	43	√	√	√	√	√
T	91	S	0.01	2.5					√
Q	92	R	0.13	1.3
C	95	F	0.02	2.6			√		√
		L	0.01	0.20
		V	0.01	0.20

^aNonpolymorphic PI-selected mutations identified in the current analysis that were not identified in our 2005 analysis (26) are shown in boldface type.

^bA, ANRS; H, HIVDB; I, IAS-USA; L, Los Alamos National Laboratory; R, Rega. A checkmark indicates that the mutation is present on the expert list indicated.