. 2009 Aug 31;53(11):4869–4878. doi: 10.1128/AAC.00592-09

TABLE 2.

Prevalences of NRTI-selected nonpolymorphic mutations in RTI-naïve, NRTI-treated (NNRTI-naïve), and NNRTI-treated individuals^a

Consensus B reference amino acid	Position	Amino acid change	Mutation prevalence (%)			Selection index^c		NNRTI index/ NRTI index ratio	Presence of mutation on expert list from^d:
Consensus B reference amino acid	Position	Amino acid change	RTI naïve (n = 12,730)	NRTI (n = 4,598)	NNRTI (n = 8,367)^b	NRTI	NNRTI	NNRTI index/ NRTI index ratio	H	A	R	I	L
I	31	L	0.1	0.8	1.5	7.1	1.8	0.3
E	40	F	0	0.4	1.8	59	4.3	0.1
M	41	L	0.3	36	47	120	1.3	0.0	√	√	√	√	√
K	43	Q	0.3	3.4	5.9	11	1.7	0.2					√
		N	0.2	1.8	3.3	8.6	1.8	0.2
E	44	A	0	1.1	3.5	163	3.0	0.0	√	√	√		√
K	64	N	0.04	1.1	0.7	23	0.6	0.0
		H	0	0.8	1.0	119	1.1	0.0
		Y	0	0.5	0.2	67	0.4	0.0
K	65	R	0.04	2.5	4.2	50	1.7	0.0	√	√	√	√	√
D	67	N	0.01	30	41	2105	1.4	0.0	√	√	√	√	√
		G	0.10	1.3	3.8	13	2.8	0.2	√	√	√		√
		E	0.01	0.6	0.9	31	1.4	0.0	√	√			√
		S	0	0.2	0.7	27	3.5	0.1	√				√
		T	0	0.07	0.1	13	1.8	0.1	√
		H	0	0.04	0.4	9.0	5.9	0.7	√
		Del	0	0	0.2	3.0	9.5	3.2	√		√		√
T	69	D	0.05	5.8	12	102	2.0	0.0	√	√	√		√
		Ins	0	0.5	2.1	66	4.5	0.1	√	√	√	√	√
		G	0.01	0.09	0.7	7.5	6.9	0.9	√		√		√
		E	0	0.06	0.4	12.0	4.7	0.4	√
K	70	R	0.13	26	24	193	0.9	0.0	√	√	√	√	√
		E	0.01	0.4	0.6	27	1.5	0.1	√	√	√	√	√
		G	0	0.3	0.7	39	2.7	0.1	√		√
		S	0	0.1	0.2	21	1.5	0.1	√				√
		T	0.04	0.1	0.5	2.5	5.0	2.0	√
		N	0.04	0.2	0.4	4.5	2.1	0.5	√
		Q	0.01	0.1	0.3	7.5	3.1	0.4
L	74	V	0.01	3.9	17	185.8	4.3	0.0	√	√	√	√	√
		I	0.02	1.0	8.3	36.8	7.9	0.2	√	√	√		√
V	75	T	0	1.3	2.5	180.6	2.0	0.0	√	√	√		√
		M	0.04	1.2	5.3	29.1	4.3	0.1	√	√	√		√
		A	0.02	0.61	1.3	22.2	2.1	0.1	√	√	√
		S	0	0.20	0.50	30.6	2.3	0.1	√	√	√
F	77	L	0.04	1.8	2.7	42.3	1.5	0.0	√			√	√
Y	115	F	0	1.1	2.9	158.2	2.6	0.0	√	√	√	√	√
F	116	Y	0.01	1.9	2.9	136.4	1.5	0.0	√			√	√
Q	151	M	0	2.4	3.9	345.5	1.6	0.0	√	√	√	√	√
T	165	L	0.03	0.29	0.54	8.6	1.8	0.2
I	167	V	0.04	0.42	1.1	8.9	2.5	0.3
M	184	V	0.20	50	47	240.2	0.9	0.0	√	√	√	√	√
		I	0.05	1.1	2.7	19.8	2.4	0.1	√	√	√	√	√
E	203	K	0.17	3.4	10	20.0	2.9	0.1					√
		V	0.01	0.22	0.75	16.7	3.2	0.2
H	208	Y	0.21	5.3	17	24.4	3.1	0.1					√
		F	0	0.24	0.73	36.8	2.8	0.1
L	210	W	0.02	21	34	717.0	1.7	0.0	√	√	√	√	√
R	211	D	0.02	0.35	0.55	13.3	1.5	0.1
T	215	Y	0.04	33	39	757.3	1.2	0.0	√	√	√	√	√
		F	0.01	9.0	13	418.4	1.5	0.0	√	√	√	√	√
		I	0.04	1.6	2.1	31.1	1.4	0.0	√	√	√
		V	0.01	0.81	0.96	57.9	1.2	0.0	√	√	√
		C	0.12	0.50	1.7	4.2	3.3	0.8	√	√	√		√
D	218	E	0.07	4.9	11	61.8	2.3	0.0					√
K	219	Q	0.10	16	15	144.3	1.0	0.0	√	√	√	√	√
		E	0.01	3.0	8.8	140.1	2.9	0.0	√	√	√	√	√
		N	0.09	1.0	7.2	11.4	6.7	0.6	√	√	√		√
		R	0.09	1.3	5.6	13.4	4.2	0.3	√	√	√		√
		W	0	0.11	0.46	18.1	3.6	0.2	√				√
		D	0	0.04	0.77	9.1	12.0	1.3
		H	0	0.04	0.59	9.1	9.3	1.0			√
K	223	Q	0	1.3	4.7	172	3.7	0.0
		E	0.04	0.57	4.0	13	6.8	0.5
L	228	H	0.24	5.4	17	22	3.1	0.1
		R	0.05	2.3	7.5	37	3.2	0.1
A	304	G	0.05	3.0	1.4	43	0.5	0.0
N	348	I	0.18	5.5	9.7	26	1.7	0.1					√

Nonpolymorphic NNRTI-selected mutations identified in the current analysis that were not identified in our 2005 analysis (26) are shown in boldface type. The number of individuals for whom a sequence was available varies by position, with fewer individuals having sequences encompassing positions 1 to 40 and positions 240 to 350.

A total of 7,312 of 8,367 individuals also received NRTIs.

The NRTI selection index is the ratio of the prevalence of the mutation in NRTI-treated but NNRTI-naïve patients to the prevalence of the mutation in RTI-naïve patients. The NNRTI selection index is the ratio of the prevalence of the mutation in NNRTI-treated patients to the prevalence of the mutation in NRTI-treated patients.

A, ANRS; H, HIVDB; I, IAS-USA; L, Los Alamos National Laboratory; R, Rega. A checkmark indicates that the mutation is present on the expert list indicated.