TABLE 3.

Prevalences of NNRTI-selected nonpolymorphic mutations in RTI-naïve, NRTI-treated (NNRTI-naïve), and NNRTI-treated individuals^a

Consensus B reference amino acid	Position	Amino acid change	Mutation prevalence (%)			Selection indexc		NNRTI index/NRTI index ratio	Presence of mutation on expert list fromd:
			RTI naïve (n = 12,730)	NRTI (n = 4,598)	NNRTI (n = 8,367)b	NRTI	NNRTI		H	A	R	I	L
I	94	L	0.02	0.07	0.9	2.8	14	5
A	98	G	0.20	2.1	8.5	10	4.1	0.4	√	√	√	√	√
L	100	I	0.01	0.02	6.6	1.0	303	303	√	√	√	√	√
K	101	E	0.1	0.4	8.5	3.8	19	5	√	√	√	√	√
		P	0	0	2.0	1.0	93	93	√	√	√	√	√
		H	0	0.09	1.9	4.0	21	5	√
		N	0.02	0.07	0.7	2.8	11	4	√		√
K	102	N	0.02	0.02	0.5	1.5	12	8
K	103	N	0.4	0.4	43	1.0	121	121	√	√	√	√	√
		S	0.01	0.02	2.2	1.0	49	49	√	√	√		√
		H	0	0	0.2	1.0	8.7	9	√	√	√		√
		T	0.02	0.1	0.3	4.1	3.2	0.8	√	√	√		√
S	105	T	0	0.04	0.6	1.0	15	15
V	106	A	0.01	0.02	2.7	1.0	124	124	√	√	√	√	√
		M	0	0	2.2	1.0	101	101	√	√	√	√	√
E	138	Q	0.01	0.1	1.0	6.2	7.6	1
T	139	R	0.06	0.1	0.9	1.7	9.0	5
I	178	F	0	0.04	0.5	1.0	10	10
V	179	F	0	0	0.5	1.0	22	22	√	√	√	√	√
Y	181	C	0.08	0.3	27	3.6	90	25	√	√	√	√	√
		I	0.01	0	1.2	1.0	56	56	√	√	√	√	√
		V	0	0	0.7	1.0	30	30	√	√	√	√	√
Y	188	L	0.07	0.09	6.5	1.4	59	42	√	√	√	√	√
		C	0.02	0.02	1.3	1.0	30	30	√	√	√	√	√
		H	0.01	0.02	1.1	1.0	25	25	√	√	√	√	√
G	190	A	0.04	0.09	20	2.2	180	81	√	√	√	√	√
		S	0	0	3.5	1.0	350	350	√	√	√	√	√
		E	0.01	0	0.6	1.0	33	33	√	√	√		√
		Q	0	0	0.3	1.0	16	16	√	√	√		√
		C	0	0	0.2	1.0	13	13	√	√	√		√
H	221	Y	0.2	0.7	8.6	4.4	12	3			√
		C	0	0	0.3	1.0	12	12
K	223	T	0.02	0.07	1.1	2.8	16	6
P	225	H	0.01	0.02	3.7	1.0	80	80	√	√	√	√	√
F	227	L	0.05	0.2	3.3	3.5	20	6	√		√		√
		Y	0	0	0.3	1.0	14	14	√
M	230	L	0.02	0.1	1.3	5.4	9.9	2	√	√	√
Y	232	H	0.02	0	0.3	1.0	20	20
L	234	I	0.01	0	0.3	1.0	21	21			√		√
P	236	L	0.03	0.1	0.3	3.3	3.1	0.9	√		√		√
D	237	E	0.1	0.3	1.6	2.9	4.9	2
K	238	T	0.05	0.2	3.4	3.2	18	6	√		√		√
		N	0.03	0.08	0.7	2.5	6.4	3	√
V	241	M	0	0	0.3	1.0	20	20
Q	242	L	0.02	0.02	0.5	1.0	12	12
Y	318	F	0.1	0.1	1.8	1.4	9.4	7	√		√		√

^aNonpolymorphic NNRTI-selected mutations identified in the current analysis that were not identified in our 2005 analysis (26) are shown in boldface type.

^bA total of 7,312 of 8,367 individuals also received NRTIs.

^cThe NRTI selection index is the ratio of the prevalence of the mutation in NRTI-treated but NNRTI-naïve patients to the prevalence of the mutation in RTI-naïve patients. The NNRTI selection index is the ratio of the prevalence of the mutation in NNRTI-treated patients to the prevalence of the mutation in NRTI-treated patients.

^dA, ANRS; H, HIVDB; I, IAS-USA; L, Los Alamos National Laboratory; R, Rega. A checkmark indicates that the mutation is present on the expert list indicated.