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. 2009 Jul 13;53(11):4903–4906. doi: 10.1128/AAC.00640-09

FIG. 3.

FIG. 3.

Survival of cultured S. mansoni larval-stage (A) or adult-stage (B) parasites treated with PA1259, artemether, artesunate, or praziquantel. Cultured worms were treated with compounds at indicated concentrations and times to produce 100% parasite death. For the larval stage, pairwise log-rank tests indicate four groups (α = 1%): (i) PA1259 (100 μg/ml and 300 μg/ml); (ii) PA1259 (5 and 10 μg/ml), praziquantel (5 and 10 μg/ml), and artemether (300 μg/ml); (iii) artesunate (300 μg/ml); and (iv) the control. For the adult stage, pairwise log-rank tests indicate four groups (α = 1%): (i) PA1259 (100 μg/ml and 300 μg/ml), (ii) praziquantel (5 and 10 μg/ml), (iii) artemether (300 μg/ml), and (iv) artesunate (300 μg/ml), PA1259 (5 and 10 μg/ml), and the control.