TABLE 1.

Antibacterial activities of BAL0030543, BAL0030544, and BAL0030545

Organism (no. of strains)	Compound	MIC (μg/ml)			% Susceptiblea
		Range	50%	90%
MSSA (25)	BAL0030543	0.015-0.06	0.03	0.03	100
	BAL0030544	0.015-0.25	0.03	0.03	100
	BAL0030545	0.015-0.25	0.12	0.25	100
	Trimethoprim	0.25-32	1	2	92
	Daptomycin	0.12-0.25	0.25	0.25	100
	Linezolid	2-2	2	2	100
	Minocycline	0.25-0.25	0.25	0.25	100
	Moxifloxacin	0.12-4	0.12	0.25	92
	Vancomycin	0.5-1	1	1	100
MRSA (25)	BAL0030543	0.015-0.06	0.015	0.06	100
	BAL0030544	0.03-0.25	0.06	0.25	100
	BAL0030545	0.06-0.06	0.06	0.06	100
	Trimethoprim	0.12-0.25	0.25	32	80
	Daptomycin	0.12-0.25	0.12	0.25	100
	Linezolid	2-2	2	2	100
	Minocycline	0.25-0.25	0.25	0.25	100
	Moxifloxacin	0.12-4	4	8	4
	Vancomycin	0.5-1	1	1	100
hVISA (25)	BAL0030543	0.015-0.06	0.03	0.06	100
	BAL0030544	0.03-0.25	0.25	0.25	100
	BAL0030545	0.03-0.06	0.06	0.06	100
	Trimethoprim	0.06-32	1	16	80
	Daptomycin	0.25-2	0.5	0.5	96
	Linezolid	1-1	1	2	100
	Minocycline	0.12-8	0.25	0.5	92
	Moxifloxacin	0.12-4	4	4	8
	Vancomycin	1-4	1	2	96
VISA (17)	BAL0030543	0.015-0.5	0.003	0.25	100
	BAL0030544	0.03-0.5	0.25	0.5	100
	BAL0030545	0.06-8	0.06	0.5	100
	Trimethoprim	0.12-32	1	32	71
	Daptomycin	0.25-2	1	2	71
	Linezolid	0.5-2	1	2	100
	Minocycline	0.12-8	1	4	96
	Moxifloxacin	8-8	8	8	0
	Vancomycin	1-4	2	4	52
Coagulase-negative	BAL0030543	0.015-16	0.06	8	86
staphylococci (29)	BAL0030544	0.03-32	0.06	8	86
	BAL0030545	0.03-16	0.06	4	86
	Trimethoprim	0.12-32	16	32	48
	Daptomycin	0.06-0.5	0.25	0.5	100
	Linezolid	0.25-2	1	2	100
	Minocycline	0.25-8	0.5	2	96
	Moxifloxacin	0.12-8	0.25	8	55
	Vancomycin	0.5-4	1	2	100
Group A streptococci (17)	BAL0030543	0.015-0.06	0.06	0.06	100
	BAL0030544	0.06-0.06	0.06	0.06	100
	BAL0030545	0.03-0.12	0.06	0.12	100
	Trimethoprim	0.12-0.5	0.5	1	N/A
	Daptomycin	0.015-0.03	0.015	0.03	100
	Linezolid	0.5-1	1	1	100
	Minocycline	0.12-0.25	0.12	0.25	100
	Moxifloxacin	0.25-0.5	0.25	0.5	N/A
	Vancomycin	0.12-0.25	0.25	0.25	100
Group B streptococci (17)	BAL0030543	0.015-0.06	0.03	0.06	100
	BAL0030544	0.06-0.12	0.06	0.12	100
	BAL0030545	0.06-0.12	0.06	0.12	100
	Trimethoprim	0.25-2	1	1	N/A
	Daptomycin	0.015-0.06	0.015	0.06	100
	Linezolid	1-2	1	2	100
	Minocycline	0.12-32	16	32	29
	Moxifloxacin	0.25-0.5	0.25	0.5	N/A
	Vancomycin	0.12-0.25	0.25	0.25	100
Group C streptococci (13)	BAL0030543	<0.008-0.12	0.015	0.06	100
	BAL0030544	<0.008-0.25	0.06	0.06	100
	BAL0030545	0.03-0.25	0.06	0.12	100
	Trimethoprim	<0.008-8	0.5	1	N/A
	Daptomycin	0.015-0.12	0.03	0.12	100
	Linezolid	1-1	1	2	100
	Minocycline	0.12-16	0.25	4	84
	Moxifloxacin	0.25-0.5	0.25	0.5	N/A
	Vancomycin	0.12-0.5	0.12	0.5	100
Group G streptococci (12)	BAL0030543	0.015-0.06	0.03	0.06	100
	BAL0030544	0.06-0.25	0.06	0.06	100
	BAL0030545	0.03-0.12	0.03	0.06	100
	Trimethoprim	0.5-1	1	1	N/A
	Daptomycin	0.015-0.03	0.015	0.03	100
	Linezolid	1-2	2	2	100
	Minocycline	0.12-16	0.25	16	75
	Moxifloxacin	0.25-4	0.25	0.5	N/A
	Vancomycin	0.12-0.25	0.12	0.12	100
Streptococcus pneumoniae (15)	BAL0030543	0.015-0.12	0.06	0.12	100
	BAL0030544	0.03-0.25	0.12	0.25	100
	BAL0030545	0.03-0.25	0.12	0.12	100
	Trimethoprim	0.5-8	1	4	N/A
	Daptomycin	<0.008-0.5	0.06	0.12	N/A
	Linezolid	0.03-2	1	2	100
	Minocycline	0.12-8	0.25	0.25	93
	Moxifloxacin	0.12-0.5	0.25	0.25	100
	Vancomycin	0.06-0.5	0.12	0.25	100
Corynebacterium spp. (12)	BAL0030543	<0.008-8	0.06	4	83
	BAL0030544	0.015-16	0.12	4	83
	BAL0030545	<0.008-6	0.12	4	83
	Trimethoprim	0.12-16	16	16	N/A
	Daptomycin	0.03-0.12	0.06	0.12	N/A
	Linezolid	0.12-1	0.06	0.12	N/A
	Minocycline	0.06-32	2	16	N/A
	Moxifloxacin	0.25-16	1	8	N/A
	Vancomycin	0.12-0.5	0.25	0.5	N/A
Listeria monocytogenes (10)	BAL30543	0.015-0.015	0.015	0.015	100
	BAL30544	0.03-0.03	0.03	0.03	100
	BAL30545	0.06-0.06	0.06	0.06	100
	Trimethoprim	0.06-0.06	0.06	0.06	N/A
	Daptomycin	0.5-2	1	2	N/A
	Linezolid	2-2	2	2	N/A
	Minocycline	0.25-16	0.25	16	N/A
	Moxifloxacin	0.5-1	0.5	1	N/A
	Vancomycin	1-1	1	1	N/A
Streptococcus mitis (8)	BAL0030543	<0.008-0.06	<0.008		100
	BAL0030544	<0.008-0.06	0.03		100
	BAL0030545	<0.008-0.12	0.015		100
	Trimethoprim	<0.008-8	4
	Daptomycin	0.006-0.5	0.25
	Linezolid	<0.008-1	1
	Minocycline	0.25-8	0.25
	Moxifloxacin	0.12-1	0.25
	Vancomycin	<0.008-1	1

^aN/A, breakpoint not available. A breakpoint of 0.5 mg/liter was used for BAL compounds for comparison.