TABLE 2.
Simulated PK/PD parameters for treatment with 16, 64, or 100 mg/kg marbofloxacin in fractionated or single administrations
| Treatment group and total marbofloxacin dose (mg/kg) | TMSW (%) | T>MPC (%) | T>MPC/TMSW | AUC/MIC (h) | AUC/MPC (h) | Cmax/MIC |
|---|---|---|---|---|---|---|
| Fractionated administration | ||||||
| 16 | 50 | 16 | 0.31 | 4 × 189 | 4 × 12 | 4 × 54 |
| 64 | 67 | 33 | 0.49 | 4 × 756 | 4 × 47 | 4 × 217 |
| 100 | 60 | 40 | 0.67 | 4 × 1,182 | 4 × 74 | 4 × 339 |
| Single administration | ||||||
| 16 | 28 | 8 | 0.30 | 1 × 756 | 1 × 47 | 1 × 217 |
| 64 | 40 | 16 | 0.41 | 1 × 3,026 | 1 × 189 | 1 × 868 |
| 100 | 41 | 22 | 0.54 | 1 × 4,728 | 1 × 295 | 1 × 1,357 |