TABLE 1.
Drug and isolate | MIC (μg/ml)b | MBC (μg/ml) | Half-life (h) | fCmax (μg/ml)a | fCmin (μg/ml)a | T99.9% (h)a | fAUC/MIC (h−1)a | % fTb,c |
|
---|---|---|---|---|---|---|---|---|---|
>MIC | >2× MIC | ||||||||
Ceftaroline | 2.1 ± 0.2 | 17.4 ± 0.7 | 1.3 ± 0.3 | ||||||
R1629 | 0.125 (0.75) | 0.25 | 12 | 100 (100)/100 (67) | 100 (75)/100 (50) | ||||
R3804 | 0.25 (0.5) | 0.5 | 26.8 | 100 (100)/100 (67) | 100 (94)/83 (62.5) | ||||
R4039 | 0.5 (1) | 1 | 6.5 | 100 (94)/83 (62.5) | 100 (69)/62.5 (46) | ||||
R494 | 0.5 (1.2) | 0.5 | 28.3-35 | 100 (85)/83 (57) | 94 (62.5)/62.5 (42) | ||||
R5200 | 1 (1) | 1 | 6.8 | 94/62.5 | 69/46 | ||||
Mu3 | 2 (2) | 2 | 5.05-44 | 69/46 | 47/31 | ||||
Vancomycin | 6.8 ± 1.6 | 18.0 ± 0.2 | 5.2 ± 1.2 | ||||||
R1629 | 1 (6) | 2 | 57.9 | ||||||
R3804 | 0.5 | 1 | 231.8 | ||||||
R4039 | 1 | 1 | 115.9 | ||||||
R494 | 0.5 | 1 | 231.8 | ||||||
R5200 | 0.5 | 0.5 | 231.8 | ||||||
Mu3 | 2 (6) | 2 | 57.9 |
fCmax, free peak concentration of drug in serum; fCmin, free trough concentration of drug in serum; fAUC, free area under the concentration-time curve; T99.9%, time to achieve bactericidal activity with the q12h regimen.
Parentheses indicate values computed with the minimal concentration required to inhibit growth of the subpopulation determined by PAP at an initial inoculum of 107 CFU/ml.
%fT > MIC, percentage of time the q8h/q12h dosing regimen is above the MIC.