TABLE 2.
Anti-HIV-1 activities of 4′-Ed4T, d4T, 3TC, and AZT against 4′-Ed4T-resistant NL4-3 strains in TZM-bl cells
| Virus | EC50 (μM) |
|||
|---|---|---|---|---|
| 4′-Ed4T | d4T | 3TC | AZT | |
| pNL4-3 (wild type) | 0.37 ± 0.09a | 1.25 ± 0.21 | 0.65 ± 0.31 | 0.023 ± 0.02 |
| P119S | 0.51 ± 0.27 | 1.44 ± 0.16 | 0.47 ± 0.16 | 0.017 ± 0.01 |
| T165A | 0.58 ± 0.31 | 1.46 ± 0.27 | 1.08 ± 0.60 | 0.022 ± 0.01 |
| M184V | 0.98 ± 0.55 | 1.40 ± 0.40 | >60 | 0.011 ± 0.01 |
| P119S/T165A | 0.35 ± 0.10 | 2.48 ± 0.74 | 2.10 ± 0.73 | 0.026 ± 0.02 |
| P119S/M184V | 1.38 ± 0.48 | 1.55 ± 0.35 | >60 | 0.011 ± 0.01 |
| T165A/M184V | 1.32 ± 0.20 | 1.50 ± 0.93 | >60 | 0.024 ± 0.02 |
| P119S/T165A/M184V | 1.96 ± 0.27 | 1.28 ± 0.57 | >60 | 0.053 ± 0.09 |
| pTKD | 2.10 ± 0.68 | 1.00 ± 0.18 | >60 | 0.008 ± 0.001 |
a
The data represent the means ± standard deviations for three separate experiments.