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Correlations between PK parameters for total, extracellular, and intracellular activity of plectasin against S. aureus E33235 (MIC = 2 mg/liter) after 24 h. (A) fCpeak/MIC; (B) fAUC/MIC24 h; (C) fT>MIC24 h. The ordinate displays the change in CFU (corresponding to the Emax value) in peritoneal fluid between treated animals (24 h) and untreated controls (at 2 h). CFU counts marked with ¤ are estimated CFU from animals taken out before the 24-h study period was completed.
