TABLE 2.
Treatment regimens and resulting PK/PD parameters for S. aureus E33235 in the mouse peritonitis studya
| Total dose (mg) | Single dose (mg/kg) | No. of doses in 24 h | fT>MIC (h) | fAUC/MIC |
|---|---|---|---|---|
| 1.02 | 34 | 1 | 2.64 | 6.45 |
| 2.04 | 34 | 2 | 5.28 | 12.89 |
| 3.06 | 34 | 3 | 7.91 | 19.34 |
| 0.51 | 17 | 1 | 1.61 | 3.85 |
| 0.26 | 8.5 | 1 | 0.95 | 1.98 |
| 0.51 | 8.5 | 2 | 1.89 | 3.96 |
| 1.02 | 8.5 | 4 | 3.79 | 7.91 |
| 1.56 | 8.5 | 6 | 5.68 | 11.87 |
| 0.13 | 4.25 | 1 | 0.00 | 0.95 |
| 0.39 | 4.25 | 3 | 0.00 | 2.85 |
a
PK/PD parameters were calculated based on free drug concentrations (27) using GraphPad Prism. MIC for E33235 was 2 mg/liter. There were three mice per group.