TABLE 3.

Summary of mutant phenotypes compared to wild type

Mutated gene	Putative role in SREBP pathway	Defective processing	Defective turnover	Sensitivity to low O2	Ergosterol abnormality	Azole sensitivity	CoCl2 sensitivity	NaNO2 sensitivity	ROS sensitivityf	Virulence
sreI	Transcriptional factor	NDa	NDa	Yes	Yes	Yes	Yes	Yes	Yes	No
scpI	Cleavage activating protein	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Reduced
sfb2	ER-to-Golgi complex transport	Yes	Yes	Nob	Yes	Yes	No	?e	Yes	Not tested
stpI	Proteolytic cleavage	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No
kap123	Nuclear transport	Yes	Yes	Yes	No	No	Yes	No	Yes	Yes
gsk3	Phosphorylation, turnover	No	Yes	Yes	No	Yesd	Yes	Yes	Yes	No
dam1	Turnover?	No	Yes	Noc	No	No	Yes	No	Yes	Not tested

^aND, not detectable due to deletion.

^bTemperature sensitive at 37°C.

^cMutation can only be partially complemented.

^dSlightly increased susceptibility.

^eCould not be determined due to sensitivity at pH 4.

^fSensitive to at least one of the ROS reagents tested.