FIG. 8.
Model for regulation of T-strand production and delivery to the translocation pathway of the MOBF type IV secretion system (T4SS). Steps in the initiation reaction cascade (I to VII) are described in the text. The subsequent translocation process per se and the steps terminating plasmid strand transfer are not shown. Protein components are illustrated as follows: the bifunctional TraI transesterase (blue) with active site tyrosine (Tyr) and TraI helicase domains (light blue), IHF (orange), TraY (purple), TraM (green), and the T4CP TraD (yellow).