FIG. 5.

Abrogation of PhoPQ- and SPI2-dependent intracellular survival of S. Typhimurium in NO-producing, IFN-γ-primed macrophages. The percentage of wild-type (WT) S. Typhimurium and its isogenic phoQ, spiC, or phoQ spiC mutant control recovered from untreated or IFN-γ-treated macrophages from immunocompetent C57BL/6 (B6) (A) or iNOS^−/− (iNOS) (B) mice was recorded 20 h after infection. The data represent the mean percent survival ± SEM of three to six independent observations from two separate experiments. *, P value of <0.001 compared to WT controls; **, P value of <0.05 compared to phoQ controls.