FIG. 6.

mett-10 mutants enhance dynein loss-of-function phenotypes of the dhc-1(js319) allele. (A, C, and D) Most dhc-1(js319) mutant germ lines are relatively normal at both 20 and 25°C, although they exhibit polyploidy (large DNA-dense nuclei) and univalents (unpaired chromosomes in diakinesis) at very low penetrance. (B, E, and F) Double mutations between dhc-1(js319) and any mett-10 allele lead to significant enhancement of both these phenotypes, and all double mutant animals are sterile at 20°C. This set of phenotypes closely phenocopies loss of dlc-1 function in the germ line.