Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Sep 2;47(11):3530–3539. doi: 10.1128/JCM.00673-09

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2009, American Society for Microbiology

PMC Copyright notice

FIG. 4. — Application of SOFT analyses to “low” viral growth in unstimulated cervical tissue for donors 1 (a), 2 (b), and 3 (c) and % virus inhibition across donors (d). Data shown represent the viral growth in the absence (○; solid lines) or presence (dotted lines) of the candidate microbicide PRO 2000 (5 μg/ml [], 50 μg/ml [], and 500 μg/ml [▪]). Medians and interquartile ranges for replicate measurements are shown. The SOFT (↑) for donors 1 and 2 occurred at day 10, while that for donor 3 occurred at day 14. (d) Inhibition of viral infection determined using different endpoint analyses. The % virus inhibition results were compared for PRO 2000 (5, 50, and 500 μg/ml) for three donor cervical tissue explant tissue samples from one laboratory. Virus inhibition (%) was calculated using p24 measurements for (i) SOFT, (ii) day 10, and (iii) day 14 endpoint analyses. The median and interquartile ranges across replicates and donors are shown. Virus inhibition for each treatment was compared to that for the Ba-L control at SOFT, day 12, and day 14 (Wilcoxon signed-rank test; *, P < 0.05; **, P < 0.01).

Inline graphic — Application of SOFT analyses to “low” viral growth in unstimulated cervical tissue for donors 1 (a), 2 (b), and 3 (c) and % virus inhibition across donors (d). Data shown represent the viral growth in the absence (○; solid lines) or presence (dotted lines) of the candidate microbicide PRO 2000 (5 μg/ml [], 50 μg/ml [], and 500 μg/ml [▪]). Medians and interquartile ranges for replicate measurements are shown. The SOFT (↑) for donors 1 and 2 occurred at day 10, while that for donor 3 occurred at day 14. (d) Inhibition of viral infection determined using different endpoint analyses. The % virus inhibition results were compared for PRO 2000 (5, 50, and 500 μg/ml) for three donor cervical tissue explant tissue samples from one laboratory. Virus inhibition (%) was calculated using p24 measurements for (i) SOFT, (ii) day 10, and (iii) day 14 endpoint analyses. The median and interquartile ranges across replicates and donors are shown. Virus inhibition for each treatment was compared to that for the Ba-L control at SOFT, day 12, and day 14 (Wilcoxon signed-rank test; *, P < 0.05; **, P < 0.01).