TABLE 1.
Characteristics of antibiotic susceptibility phenotypes of the French N. gonorrhoeae isolates studied
| Phenotype (no. of strains) | Antibiotic susceptibility (MIC [mg/liter]) toa: |
||||||
|---|---|---|---|---|---|---|---|
| Penicillin | β-Lactamase | Tetracycline | Ciprofloxacin | Ceftriaxone | Spectinomycin | Erythromycinb | |
| 1 (10) | R (1-4) | Positive | hR (16-32) | I or R (0.5-4) | S (≤0.004) | S (4-8) | S |
| 2 (6) | I (0.064-0.19) | Negative | hR (16-32) | I or R (0.5-2) | S (≤0.004) | S (4-6) | S |
| 3 (39) | S or I (≤1) | Negative | S or I (0.125-1) | S (<0.002-0.012) | S (≤0.004) | S (4-12) | S |
| 4 (31) | I (1-1.5) | Negative | I or R (1.5-3) | hR (≥32) | rS (0.016-0.032) | S (4-8) | S |
| 5 (2) | I (0.5-0.75) | Negative | R (2) | S (0.008-0.012) | rS (0.012-0.016) | S (6-8) | S |
| 6 (5) | I (0.125-0.75) | Negative | I or R (1-2) | R or hR (4-32) | S (0.003-0.016) | S (4-8) | S |
a
The antimicrobial MIC interpretative standards and breakpoints for susceptibility and resistance (CLSI) for the antibiotics shown are as follows: penicillin MIC, ≥0.06 and ≥2; tetracycline MIC, ≥0.25 and ≥2; ciprofloxacin MIC, ≥0.06 and ≥1; ceftriaxone MIC, ≥0.5 and ≥1; and spectinomycin MIC, ≥32 and ≥64. S, susceptible; I, intermediate; R, resistant; rS, reduced susceptibility (ceftriaxone MIC, ≥0.012 and ≤0.032 mg/liter); hR, high level of resistance (tetracycline MIC, ≥16 mg/liter; ciprofloxacin MIC, ≥32 mg/liter).
b
Only the disk diffusion method was used for erythromycin.