TABLE 3.
Microbiological and molecular characteristics of seven VIM-1-producing E. cloacae strains
| Strain | Pulsed-field gel electrophoresis clone | Genetic element | Mechanism of resistance | MIC (mg/liter)a |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IPM | MEM | ERT | TIGE | CEF | CAZ | ATM | PIP/T | AMP | LEV | AK | COL | ||||
| 3442 | A | Plasmid int1 blaVIM-1; Int1-aadA2 | VIM-1 + SHV-12 | 2 | 2 | 8 | 0.5 | >64 | >128 | >128 | >128 | >32 | 32 | 0.5 | 0.5 |
| 63016 | A | Plasmid int1 blaVIM-1; Int1-aadA2 | VIM-1 + SHV-12 | 1 | 2 | 4 | 0.5 | >64 | >128 | 128 | >128 | >32 | 32 | 0.5 | 0.25 |
| 67141 | A | Plasmid int1 blaVIM-1; Int1-aadA2 | VIM-1 + SHV-12 | 2 | 2 | 2 | 1 | 64 | >128 | 128 | >128 | >32 | >32 | 1 | 0.5 |
| 67110 | B | Plasmid int1 blaVIM-1; Int1-aadA2 | VIM-1 | <0.12 | 0.5 | 0.5 | 0.5 | 8 | >128 | 16 | 32 | >32 | <0.03 | 4 | >256 |
| 68722 | B | Plasmid int1 blaVIM-1 | VIM-1 + TEM-1 | <0.12 | <0.12 | 0.25 | 0.5 | 1 | 128 | 64 | 64 | >32 | <0.03 | 1 | 256 |
| 2270 | C | int1 blaVIM-1 | VIM-1 | 0.25 | 0.06 | 0.25 | 0.12 | 0.12 | >128 | 4 | 32 | >32 | <0.03 | 32 | 2 |
| 2971 | D | int1 blaVIM-1 | VIM-1 | 1 | 0.12 | 1 | 0.5 | 2 | 128 | 4 | 64 | >32 | <0.03 | 1 | 0.5 |
a
IPM, imipenem; MEM, meropenem; ERTA, ertapenem; TIGE, tigecycline; CEFE, cefepime; CAZ, ceftazidime; ATM, aztreonam; PIP/T, piperacillin-tazobactam; AMP, ampicillin; LEV, levofloxacin; AK, amikacin; COL, colistin.