TABLE 1.
Classification and code no. | Resistance to H, E, and Sa | rpoB mutation | Treatment |
Country of origin | ||
---|---|---|---|---|---|---|
Regimenc | Outcome | Relapse | ||||
R1 | None | Ser531Leu | Cat. 1 | Failure | NAd | Bangladesh |
R2 | HE | Leu511Pro | Cat. 2 | Failure | NA | Bangladesh |
R3 | HES | Leu511Pro | Cat. 2 | Failure | NA | Bangladesh |
R4 | H | Asp516Tyr | Cat. 2 | Failure | NA | Bangladesh |
R5 | HES | Asp516Tyr | Cat. 2 | Failure | NA | Bangladesh |
R6 | HS | Asp516Tyr | Cat. 2 | Failure | NA | Bangladesh |
PR1 | HES | Asp516Tyr | Unknown | Unknown | Unknown | DR Congo |
PR2 | HES | Leu533Pro | Unknown | Unknown | Unknown | Azerbaijan |
PR3 | None | Leu533Pro | Cat. 2 | Cure | Yes | Bangladesh |
PR4 | H | His526Leu | Cat. 2 | Cure | Yes | Bangladesh |
PR5 | None | His526Ser | Cat. 2 | Cure | Yes | Bangladesh |
PR6 | HE | Leu511Pro | Cat. 2 | Cure | Yes | Bangladesh |
PR7 | HE | Met515Ile Asp516Tyr | Cat. 2 | Cure | Yes | Bangladesh |
PR8 | None | Ile572Phe | Cat. 2 | Cure | No | Bangladesh |
PS1 | H | WTb | Cat. 2 | Cure | Yes | Bangladesh |
PS2 | H | WT | Cat. 2 | Failure | NA | Bangladesh |
PS3 | HES | WT | Cat. 2 | Failure | NA | Bangladesh |
S1 | None | WT | Cat. 2 | Cure | No | Bangladesh |
S2 | None | WT | Cat. 1 | Cure | No | Bangladesh |
H, isoniazid; E, ethambutol; S, streptomycin.
WT, wild type, no mutation found.
Cat. 1, Cat. 2, WHO standard first-line treatment regimens: category 1 for new cases and category 2 for retreatment cases (see the text).
NA: not applicable.