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. 2009 Sep 16;47(11):3501–3506. doi: 10.1128/JCM.01209-09

TABLE 1.

Panel strain classification and characteristics

Classification and code no. Resistance to H, E, and Sa rpoB mutation Treatment
Country of origin
Regimenc Outcome Relapse
R1 None Ser531Leu Cat. 1 Failure NAd Bangladesh
R2 HE Leu511Pro Cat. 2 Failure NA Bangladesh
R3 HES Leu511Pro Cat. 2 Failure NA Bangladesh
R4 H Asp516Tyr Cat. 2 Failure NA Bangladesh
R5 HES Asp516Tyr Cat. 2 Failure NA Bangladesh
R6 HS Asp516Tyr Cat. 2 Failure NA Bangladesh
PR1 HES Asp516Tyr Unknown Unknown Unknown DR Congo
PR2 HES Leu533Pro Unknown Unknown Unknown Azerbaijan
PR3 None Leu533Pro Cat. 2 Cure Yes Bangladesh
PR4 H His526Leu Cat. 2 Cure Yes Bangladesh
PR5 None His526Ser Cat. 2 Cure Yes Bangladesh
PR6 HE Leu511Pro Cat. 2 Cure Yes Bangladesh
PR7 HE Met515Ile Asp516Tyr Cat. 2 Cure Yes Bangladesh
PR8 None Ile572Phe Cat. 2 Cure No Bangladesh
PS1 H WTb Cat. 2 Cure Yes Bangladesh
PS2 H WT Cat. 2 Failure NA Bangladesh
PS3 HES WT Cat. 2 Failure NA Bangladesh
S1 None WT Cat. 2 Cure No Bangladesh
S2 None WT Cat. 1 Cure No Bangladesh
a

H, isoniazid; E, ethambutol; S, streptomycin.

b

WT, wild type, no mutation found.

c

Cat. 1, Cat. 2, WHO standard first-line treatment regimens: category 1 for new cases and category 2 for retreatment cases (see the text).

d

NA: not applicable.