FIG. 5.

The integrin headpiece forms the ring and connector regions stretching away from the penton base in the HAdV12/αvβ5 structure. (A) The additional integrin headpiece domains are labeled. The RGD-binding integrins domains are modeled above the penton base as in Fig. 4. This is a composite integrin headpiece model built from PDB-IDs 1L5G and chain B of 2VDK with a 69° angle between the β-chain I and hybrid domains (38). (B) The penton base is shown with four docked copies of the integrin headpiece. (C) The penton base is shown with simulated density (light blue) generated from the integrin models in panel B with fivefold averaging and filtered to 27-Å resolution.