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. 2009 Sep 16;83(22):11890–11901. doi: 10.1128/JVI.00864-09

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Copyright © 2009, American Society for Microbiology

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FIG. 5. — Amino acid variation in the VP2 minor capsid protein of representative strains over time. The GII.4 strains from the study of the Children's Hospital in Washington, DC, were compared with representative strains from the clusters previously proposed for GII.4 VP1 evolution (32) as follows: CHDC2094, Hu/NoV/GII.4/CHDC2094/1974/US; CHDC5195, Hu/NoV/GII.4/CHDC5191/1974/US; CHDC4871, Hu/NoV/GII.4/CHDC4871/1977/US; CHDC4108, Hu/NoV/GII.4/CHDC4108/1987/US; CHDC3967, Hu/NoV/GII.4/CHDC3967/1988/US; Camberwell, Hu/NoV/GII.4/Camberwell/1994/AUS; Dresden, Hu/NoV/GII.4/Dresden/1997/GER; F. Hills, Hu/NoV/GII.4/Farmington Hills/2002/US; GII.4/2004, Hu/NoV/GII.4/MD-2004/2004/US; Sakai, Hu/NoV/GII.4/Sakai/2005/JP. VA387, Hu/NoV/GII.4/VA387/1998/US was included for comparison (see Table S1 in the supplemental material for GenBank accession numbers). Positions predicted to evolve under positive selection are highlighted in green.