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. 2009 Sep 9;83(22):11456–11466. doi: 10.1128/JVI.00884-09

FIG. 1.

FIG. 1.

FIG. 1.

Sequence variability across the HCV subtype 3a genome identifies two novel HVRs within E2. (A) The entropy score (a mathematical measure of variability) at each amino acid site following full-length viral genome sequence analysis of 18 patients with chronic HCV genotype 3a infection is shown. Each bar represents variability at a single amino acid site. The corresponding HCV subtype 3a genome map is given above. Analysis of E2 subtype 3a shows the HVR1 at the N-terminal domain of E2, in addition to two novel hypervariable regions (HVR495 and HVR575). (B) For comparison, we show the E2 entropy scores from 31 patients with HCV subtype 1a, 27 patients with subtype 1b, 20 patients with subtype 2a, 15 patients with subtype 4a, and 15 patients with subtype 6a infection (sequences were determined in house with additional sequences derived from the Los Alamos and euHCVdb HCV databases).