FIG. 5.

Hydrophobicity or hydrophilicity of the amino acids that comprise the novel HVRs. The data are derived from E2 amino acid sequence in 18 patients with chronic HCV infection. The HVR495 and HVR575 regions are shown. The numbers given are amino acids relative to the genotype 1a H77 sequence. The percentage of individuals expressing a particular amino acid at each site is given. Amino acids are classified as hydrophobic, neutral, and hydrophilic. The star graphic highlights sites under positive selection as defined by CODEML analysis.