. 2009 Sep 9;83(22):11830–11846. doi: 10.1128/JVI.01466-09

TABLE 4.

Summary of phenotypes in inducible Nef DTg mice

Mouse and founder line	Sex	Expt^b	Phenotype^a
			CD4 downregulation		Thymocyte loss				pLN total cell loss			Effector/memory	Proteinuria	Nonlymphoid organ diseases^c
			Thymus	pLN	Total	CD4⁺ CD8⁻	CD8⁺ CD4⁻	CD4⁺ CD8⁺	Total	CD4⁺	CD8⁺	Effector/memory	Proteinuria	Nonlymphoid organ diseases^c
CD4C/rtTA × TRE/HIV^Nef
F148571	Male^d	M	++	+	+	++	+	+	++	+++	+	++	−	−
	Female	L	+	−	−	−	−	−	−	−	−	−	−	−
CD4C/rtTA2^S-M2 × TRE/HIV^Nef
F176042	Male^d	H	++	+	+++	+++	+++	+++	+++	+++	+++	ND^e	+++	+++
	Female	M	++	−	+	+	+	+	+	++	+	+++	++	++
F176043	Male^d	H	++	++	+++	+++	++	+++	+++	+++	+++	ND^e	+++	+++
	Female	M	++	−	−	+	+	−	++	++	++	++	++	+

The most severe phenotype shown after DOX induction for each DTg line.

Nef expression: H, high; M, moderate; L, low.

Scored at 6 months after DOX induction, except for males of F176042 and F176043 lines, which were scored after 1 and 6 weeks.

All phenotypes seen within 6 weeks of DOX induction.

ND, not determined; the number of pLN T cells was too low to determine this phenotype.