FIG. 5.

The cytotoxic capacity of HIV-specific CD8⁺ T cells of LTNP is significantly greater than that of HIV-specific CD8⁺ T cells of Rx <50. (A and B) Summary data for the total cytotoxic responses measured by GrB activity (A) or ICE (B) with day 0 or day 6 CD8⁺ T cells derived from LTNP (red symbols, n = 17) and Rx <50 (blue symbols, n = 17). Horizontal lines indicate median values. Comparisons were made using the Wilcoxon two-sample or signed rank test. (C) Using day 6 CD8⁺ T cells, GrB target cell activity correlates directly with ICE (n = 34). (D and E) With day 6 CD8⁺ T cells, HIV-specific CD8⁺ T-cell proliferation directly correlates with both GrB target cell activity (D) and ICE (E). Statistical analyses were performed using the Spearman correlation.