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Model for the roles of MAPK in chondrocyte and osteoblast differentiation. While MAPK inhibits chondrogenic differentiation of osteo-chondroprogenitor cells, MAPK enhances osteoblast differentiation. MAPK is essential for osteoblast differentiation into Osteocalcin-expressing mature osteoblasts. MAPK also inhibits hypertrophic chondrocyte differentiation.
