Skip to main content
. 2009 Aug 24;29(21):5900–5910. doi: 10.1128/MCB.00419-09

FIG. 8.

FIG. 8.

Model depicting USF-mediated regulation of β-globin gene expression. The expression of USF increases during the differentiation of erythroid cells. USF regulates the recruitment of transcription complexes to the β-globin gene locus by interacting with E-boxes located in LCR element HS2 and in the adult β-globin gene promoter. Through the LCR, USF regulates the expression of the embryonic genes. USF further regulates the expression of the globin genes indirectly by enhancing the expression of erythroid cell-specific transcription factors with which it cooperates in mediating the recruitment of transcription complexes to the globin gene locus.