Skip to main content
. 2009 Aug 31;29(21):5828–5842. doi: 10.1128/MCB.00945-09

FIG. 11.

FIG. 11.

Hypoxia and NOR-1 attenuation/overexpression differentially modulate genes involved in cell survival. (A to C) HUVEC were transfected with either siRNA control silencer (siControl) or siNOR-11 against NOR-1 (siNOR-1) and exposed to normoxia or hypoxia (1% O2) for 24 h. mRNA levels of cIAP1, cIAP2, and cyclin D1 were determined by real-time PCR and were expressed relative to those of cells transfected with siControl and exposed to normoxia. Shaded bars, HUVEC were transfected with either a plasmid (pEGFP-NOR-1) that overexpresses NOR-1 (NOR-1) or the corresponding control vector (pIRES2-EGFP; Control). mRNA levels of cIAP1, cIAP2, and cyclin D1 were determined by real-time PCR 24 h later and were expressed relative to those of cells transfected with the control vector. Data represent means ± SEM (n = 6). *, P < 0.05 versus cells transfected with siControl and exposed to normoxia; #, P < 0.05 versus cells transfected with siControl and exposed to the same treatment (either normoxia or hypoxia); **, P < 0.05 versus cells transfected with the control vector (Control).