FIG. 1.

Increased sensitivity of mice lacking Abr or Bcr to LPS-induced endotoxemia. The body weight loss and regain of the indicated genotypes given LPS (15 mg/kg given i.p.) is shown. Genotypes include abr^−/− (squares; n = 4), bcr^−/− (triangles; n = 4), and wild type (circles; n = 6). Body weights are normalized to baseline weight in each animal. *, P < 0.01 by paired Student's t test compared to results for abr^−/− and bcr^−/− mice. Only weights of surviving mice are included in the graphs, and all genotypes were on the FVB/J background.