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. 2009 Aug 24;29(21):5742–5750. doi: 10.1128/MCB.00357-09

FIG. 3.

FIG. 3.

Increased sensitivity of mice lacking abr and bcr to CLP. (A) Seven to eight sets of 8- to 10-month-old sibling female wild-type (wt) or abr × bcr−/− mice were subjected to CLP. Weight loss is indicated as the percentage of original body weight at 24 and 48 h after CLP. *, P < 0.01 by paired Student's t test. (B) Percentage of mice surviving at the indicated times (n = 9 wild-type mice and 10 abr × bcr−/− mice). (C) Increased intestinal damage to the ileum of abr × bcr−/− mice 48 h after CLP. Magnifications and genotypes are indicated. Scale bars, 100 μm. (D) Decreased villus length and increased goblet cell number in mice lacking Abr and Bcr. #, P < 0.05 compared to results for sham operation; *, P < 0.05 compared to results for wild-type CLP. For sham-operated mice, n = 2; for wild-type CLP and abr × bcr−/− CLP mice, n = 3 in each group (30 villi from each mouse). (E) Elevated ALT and AST levels in plasma of abr × bcr−/− mice. P < 0.005 (*) and P < 0.001 (**) compared to results for sham operation and PBS. ⋄, P < 0.05 compared to results for abr × bcr−/− by paired t test. (A, B, C, and E) Mice on outbred background; (D) mice on inbred background.