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. 2009 Aug 24;29(21):5872–5888. doi: 10.1128/MCB.00112-09

FIG. 8.

FIG. 8.

NAPRT1 status of human tumor cell lines. (A) Frequency of rescue from GMX1778 cytotoxicity (30 nM) by 10 μM NA or 10 μM NAMN in a panel of human tumor cell lines. Cytotoxicity was measured at 72 h. (B) NAPRT1 mRNA levels measured by qRT-PCR and normalized to GAPDH mRNA expression. Statistical significance was determined by Student's t test with Welch's correction; P values are indicated. (C) Western blot of NAPRT1 protein expression in cytosolic extracts (30 μg) from human tumor cell lines that were rescued or not rescued from GMX1778 cytotoxicity by NA as indicated.