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. 2009 Aug 19;83(21):11298–11306. doi: 10.1128/JVI.01147-09

FIG. 1.

FIG. 1.

E1 D188 conservation in alphaviruses and location in the E1 homotrimer. (A) Side view of the structure of the postfusion SFV E1 homotrimer (Protein Data Bank accession number 1RER) (16). DI is shown in red, DII in yellow, DIII in blue, the DI-DIII linker in black, the stem in purple, and the fusion loop (FL) at the tip of DII in green. D188 in the gh loop in the core trimer interface is represented in a space-filling model in gray. (B) Comparison of the amino acid sequences of the alphavirus E1 gh loop, residues 179 to 196 (SFV E1 numbering). Residues that are identical to the SFV sequence are represented as dots, and D188 is shown in red. The alphaviruses are SFV, Barmah Forest virus (BFV), eastern equine encephalitis virus (EEEV), Igbo Ora virus (IOV), Middelburg virus (MIDV), Ndumu virus (NDUV), salmon pancreas disease virus (SPDV), sleeping disease virus (SDV), chikungunya virus (CHIKV), o'nyong-nyong virus (ONNV), Ross River virus (RRV), Trocara virus (TROV), Venezuelan equine encephalitis virus (VEEV), Aura virus (AURAV), Sindbis virus (SIN), western equine encephalitis virus (WEEV), HbB17, and M1. (C) View looking into the core trimer interface, oriented with the fusion loops pointing at the viewer. The three E1 monomers are shown in red, blue, and green. D188 is represented in yellow as a stick drawing, with oxygen and nitrogen atoms drawn in red and blue, respectively.