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Functional implications of the N-terminal ZF domain in nsp1α. (A) Tetrahedral coordination of the zinc ion. The zinc ion and four coordinated cysteine residues are covered with a 2Fo-Fc electron density map phased with a MAD data set and contoured at 1.0 σ (cyan). (B and C) Top and side views of the hydrophilic groove on the molecular surface of the nsp1α homodimer.
