FIG. 8.

Box plots (ratio of median FCs on a log scale; y axis) showing susceptibilities of viruses with V82A and V82A/L90M mutations to various PIs (x axis) in the presence (green boxes) or absence (yellow boxes) of associating mutations within the NC-p1 and p1-p6 cleavage sites. The boxes represent the interquartile range between the first and third quartile. The upper and lower lines represent 1.5 times the upper and lower quartile limits. The black line represents the median, and the red X represents the mean of the distribution. Outliers are shown as open circles. Dark green and gold boxes indicate a significant effect of associating mutations within Gag cleavage sites on PI susceptibilities. Susceptibilities are shown as follows: viruses with mutation V82A with and without mutations at Gag 431 (a), viruses with mutation V82A/L90M with and without mutations at Gag 431 (b), viruses with mutation V82A with and without mutations at Gag 437 (c), viruses with mutation V82A/L90M with and without mutations at Gag 437 (d), viruses with mutation V82A with and without mutations at Gag 449 (e), viruses with mutation V82A/L90M with and without mutations at Gag 449 (f), viruses with mutation V82A with and without mutations at Gag 453 (g), and viruses with mutation V82A/L90M with and without mutations at Gag 453 (h). P values of ≤0.05 are significant.