FIG. 5.

Vaccinated macaques have an improved control of viremia compared to unvaccinated and GFP control animals. Plasma viral loads were monitored for 5 months postchallenge, twice a week during the first 3 weeks, then once a week during the next 3 weeks and finally once a month. Viremia of unvaccinated (panel A in blue), GFP control (panel A in green), and vaccinated animals (panel B in red), as well as the geometric mean for the naive and GFP control group (in black) versus the vaccinated group (in gray) (A to C) are shown. The geometric mean of viral replication levels was lower in the vaccinated group at all time points tested (C). An average 2 log₁₀ fold reduction of viremia was observed at the peak of acute infection (E). The geometric mean viremia of the vaccinated animals (in gray) was also compared to that of progressor animals (14184, 21544, and 20456) in orange and of slow progressor animals (15661, 15885, and 14468) in light blue (D). Post-acute-phase viremia levels were lower in vaccinated animals than in progressor animals. *, P < 0.05.