Table 1.

Impact of T/E₂ Depletion vs Repletion on GH Secretion^*

Endpoint	Leuprolide + Pl (N = 13)	Leuprolide + T (N = 11)	P value
Basal (nonpulsatile) GH secretion	2.3 ± 0.52	4.0 ± 0.94	0.019
Unstimulated pulsatile GH secretion	5.1 ± 2.6	4.9 ± 1.6	P > 0.10
L-arginine/GHRH stimulation	117 ± 19	103 ± 15	P > 0.10
L-arginine/GHRP-2 stimulation	235 ± 27	273 ± 41	P > 0.10

^*Units are μg/L/3 h.

Data are the mean ± SEM.

P values were estimated by an unpaired one-tailed Student's t-test under the prior hypothesis that T/E₂ depletion lowers GH output.